Our Approach

We believe that the degradation of toxic cellular components, whether they are damaged organelles or aggregated proteins, is a fundamental node of biology. Mutations that impair these clearance pathways are causative in multiple neurodegenerative diseases, many of which are associated with cognitive dysfunction.

We aim to leverage our understanding of these critical pathways to discover and develop novel small molecules that will restore cellular balance and treat neurodegenerative and rare diseases. Rheostat is actively targeting autophagy and mitophagy pathways. We believe that dialing up these pathways in disease states will attenuate neuronal dysfunction and senescence.